… first report of a cytotoxic granule protein that enhances lysis by perforin. The protein, PEPr,
increases the number of red cells that are lysed by fixed amounts of perforin. PEPr appears …

… unknown perforin inhibitor that is associated with cytotoxic granule … Dry NaCl was added to
increase the salt concentration to 1.15 M. … The low molecular weight protein bands contained …

… Calreticulin is the only KDEL protein found in cytotoxic lymphocyte granules, which … that
the increase in specific gravity of granules over the specific gravity of water was due to the …

… Our RNK-16 subline has retained granule lytic activity while … and irreversible conformation
that will not enhance lysis. … At this time, perforin and perforin enhancing protein (PEPr; …

… specialized granules that contain potent cytotoxic molecules. … that perforin secretion from
the lytic granules caused cell … , perforin-deficient mice show enhanced lymphocyte expansion …

… Perforin was purified from a mouse cytotoxic lymphocyte cell line (CTLL-R8.6) as reported …
of perforin by an increase in the pH of lytic granules.61 To inhibit perforin-mediated cytotoxicity…

… an increase in the granule pH, the granules become irregularly shaped and loose the small
… Thus, a mechanism to protect the cytotoxic lymphocyte from perforinmediated lysis must …

… Moreover, a previously characterised “perforin-enhancing protein”, … ) Perforin-enhancing
protein, a low molecular weight protein of cytotoxic lymphocyte granules, enhances perforin lysis…

… to mycoplasma infection, lymphocytes were isolated from cell … with perforin and block the
lytic activity of the granule extracts… with an increase in IFN-γ production. The BAL cells show an …

… Granulysin-induced apoptosis is associated with an increase in ceramide content and a …
perforin enhancing protein and that perforin and granulysin act individually to induce lysis. …